Genomics

Chris Evert and the Imperative of Studying Genetic Variants

January 19, 2022 | by Lea Starita

We generate data in our research labs to inform the classification of variants found in people like Chris and Jeanne Evert.

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Looking Back and Projecting Ahead as AVE Celebrates One Year

October 21, 2021 | by BBI Communications

This October marks the one-year anniversary of the Atlas of Variant Effects (AVE) Alliance.

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BBI’s Dr. Doug Fowler: Q&A on NHGRI’s Bold Predictions for Human Genomics by 2030

September 21, 2021 | by BBI Communications

BBI’s Dr. Doug Fowler on September 16 presented at a National Human Genome Institute’s (NHRGI) “Bold Predictions”: The clinical relevance of all encountered genomic variants will be readily predictable, rendering the diagnostic designation “variant of uncertain significance (VUS)” obsolete.

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NIH Awards BBI Researchers $16 million as Part of ‘Impact of Genome Variation on Function’ Consortium

September 09, 2021 | by Written by Michael McCarthy for UW Medicine Newsroom

The National Institutes of Health has awarded $16 million to UW Medicine scientists and their collaborators to fund two projects within the consortium. The funding is part of a 5-year, $185-million initiative sponsored by the NIH’s National Human Genome Research Institute.

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Interns Advance BBI’s Work as They ‘Deepen Knowledge and Experience’

August 18, 2021 | by Gailen Greenstein

This year BBI has three undergraduate interns working at the Fred Hutch, Seattle Children’s Hospital, and the UW Medicine: Amira Ellison, Heidi Solis, and Maria E. Benitez-Cortez. Here, each one offers insights into their passions for their work.

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Exploring Underlying Causes of Mendelian Conditions Difficult to Solve

July 16, 2021 | by BBI Communications

NIH Funds BBI members to participate in new Mendelian Genomics Research Consortium

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Tailor-Made Fish Help Explain Genetic Conditions in Children

October 18, 2018 | by Lindsay Kurs, Seattle Childrens

Genetically engineered fish advance the study of how different genes affect development and cause disease.

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NIH visits UW to explain why they want your genome

November 05, 2018 | by Katherine Long, Seattle Times staff reporter

The NIH is asking for volunteers in a project to sequence the genetic material of a million people living in the U.S., making it possibly the largest research project in human history.

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BRCA mutations can be deadly or harmless. Now CRISPR can tell the difference

November 08, 2018 | by Jay Shendure, Greg Findlay, Lea Starita

More than 1 million women have had genetic testing of BRCA1 and BRCA2, genes in which mutations can dramatically increase the risk for early onset breast and ovarian cancer. But for many women the test results have been ambiguous.

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Drugs could treat some aneurysms, gene study suggests

June 10, 2019 | by Michael McCarthy

The study shows how genomic analysis can identify drugs that precisely target specific disease-causing mutations.

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Technique shows how individual cancer cells react to drugs

December 06, 2019 | by UW Medicine Communications

sci-Plex profiles gene expression in thousands of individual cells when a sample is perturbed; the technology holds promise for cancer, infection, prenatal medicine and other research.

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Tests Show Genetic Signature of Virus That May Have Infected President Trump

November 01, 2020 | by By James Glanz

The White House did not take basic steps to investigate its outbreak. We worked with geneticists to sequence the virus that infected two journalists exposed during the outbreak, providing clues to how it may have spread.

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The Problem with Direct-to-Consumer Genetic Tests

March 10, 2020 | by Heather Cheng, M.D., Ph.D.

Despite caveats in ads and on packages, users can fail to understand their limitations

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UW Scientists Develop Technique that Can Track Gene Activities as Cells Grow and Adapt

April 13, 2020 | by BBI Communications

The dynamics of gene expression across the genome can be characterized as a cell develops, and as it responds to challenges.

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TOPMed: Q&A with BBI’s Dr. Debbie Nickerson, PhD

February 10, 2021 | by BBI Communications

February 10 marked the first public release of data from the international Trans-Omics for Precision Medicine (TOPMed) program, one of the world’s largest genome sequencing projects ever conducted. BBI’s Debbie Nickerson and her researchers have and will continue to play a significant role.

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