Our Research Defines Us

The goal of BBI’s tools and platforms is to enable our members to explore new opportunities at the interface of basic science and precision medicine.

Below are some recent examples of our work.

UW Medicine Fred Hutch Seattle Children's Hospital

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Sea Hub

The Brotman Baty Institute & The Seattle Hub for Synthetic Biology

Lead Researchers

Jay Shendure, Cole Trapnell, Marion Pepper, Sud Pinglay, Nobuhiko (Nobu) Hamazaki
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Mutational Scanning

Variant Effects Analysis Program

Lead Researchers

Lea Starita, Doug Fowler, Jay Shendure, Andrew Stergachis
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Genomics

BBI Advanced Technology Lab

Lead Researchers

Lea Starita

Jay Shendure

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Welcome to The Brotman Baty Institute

Welcome to The Brotman Baty Institute, an innovation hub for genomic research and precision medicine.

The BBI is a collaboration among Seattle’s three top research institutions—The University of Washington, Seattle Children’s Hospital, and Fred Hutchinson Cancer Research Center.

The offices of the Brotman Baty Institute and the UW Campus overlook Seattle’s Montlake Cut, Lake Union, and the city skyline. Photo courtesy of University of Washington Communications.

The offices of the Brotman Baty Institute and the UW Campus overlook Seattle’s Montlake Cut, Lake Union, and the city skyline. Photo courtesy of University of Washington Communications.

Our Resources

Investigators based at partner institutions have equal access to our platforms at identical costs.

Tools & Data

BBI tools and data support BBI members and researchers worldwide.

BBI provides data and a repository for our datasets, analysis code, and protocols. We also provide tutorials to assist you in downloading, analyzing, and exploring these datasets.

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Platforms

BBI Platforms support our research.

Our goal is to support the work of our faculty, researchers, and investigators by fostering collaboration and innovation.

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BBI Grant Program

The BBI invests in promising pilot research.

The Brotman Baty Institute (BBI) aims to create a community of investigators across the three founding institutions (UW, Fred Hutch, Seattle Children’s) to advance basic science and translational research with clear relevance to precision medicine. The BBI invests in innovative, collaborative projects that address basic science or translational research questions related to precision medicine. To learn more about the grants offered by BBI and to apply, contact info@brotmanbaty.org.

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Collaborators

BBI members include more than 300 faculty at The University of Washington, Seattle Children’s Hospital, and Fred Hutchinson Cancer Research Center.
Learn about membership at BBI

Our Commitment to Diversity, Equity, and Inclusion

BBI embraces diversity and inclusion in all its work and, like the University of Washington, believes diversity is integral to excellence.

We value and honor diverse experiences and perspectives, strive to create welcoming and respectful learning environments, and promote access, opportunity, and justice for all.

News

Q and A with Dr. David Adams on MSS 2025 and Prospects for Completing a Clinical Atlas of Variant Effects

February 20, 2025 | by BBI Communications

Dr. David Adams, founding member of the Atlas of Variant Effects Alliance, will be a featured speaker at the Eighth Annual 2025 Mutational Scanning Symposium, May 21 to 23, in Barcelona

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UW Medicine Huddle: Mapping Genetic Variants and Their Ties to Disease

February 13, 2025 | by Matt Fitzsimons, UW Medicine

Accelerating discoveries: UW Medicine and the Brotman Baty Institute lead a worldwide effort; Scientists are on track to map 1,000 genes by 2030; and Patients and families are already seeing benefits.

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Q&A with Dr. Sudarshan Pinglay on Paper Regarding Structural Variants and Genome-Shuffle-Seq

February 12, 2025 | by BBI Communications

Dr. Pinglay and UW Genome Sciences researchers recently published, “Multiplex generation and single cell analysis of structural variants in mammalian genomes” in the journal Science. That study, in tandem with another paper by the Wellcome Sanger Institute, advance the study of structural variants.

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