News | Brotman Baty Institute

‘Inventor of the Year’ Jay Shendure Thanks Donors Whose Flexible Funding Enables Research ‘Freedom’

November 08, 2022 | by BBI Communications

Several dozen friends, family members, and supporters attended an event September 13 honoring BBI’s Scientific Director Dr. Jay Shendure, who was named “Inventor of the Year” by UW Medicine and UW’s CoMotion.

2022 Business Journal Women of Influence honoree Alice Berger leads a cancer biology lab at the Fred Hutchinson Cancer Center

November 03, 2022 | by Brooke Strickland – Contributing writer, PSBJ

NOTE: BBI congratulates Dr. Alice Berger, who will be honored November 10th by the Puget Sound Business Journal as a 2022 “Woman of Influence.” This article is the publication’s profile of her and her work.

Promising Young Scientist Sam Regalado: Inspired by a Desire to Advance Opportunities for People of Diverse Cultures

November 03, 2022 | by BBI Communications

‘The best science is that done in a multi-disciplinary manner’

New Grant Enables Further Testing of Reliable, Non-Invasive Pediatric Brain Cancer Platform

October 31, 2022 | by BBI Communications

‘This work exemplifies precision medicine in addressing potential relapses of brain tumors’

BBI Faculty Conversations: Dr. Lisa Maves

October 26, 2022 | by BBI

Dr. Maves is an Associate Professor in the Center for Developmental and Regenerative Medicine at Seattle Children’s Research Institute (SCRI)

BBI’s Larry Corey Receives Lifetime Achievement Award from Infectious Diseases Society of America

October 21, 2022 | by BY SABIN RUSSELL / FRED HUTCH NEWS SERVICE

Fred Hutch virologist honored by peers for his work on infectious diseases

BBI Researchers Present on their Work at International CRISPR conference

October 11, 2022 | by BBI Communications

Florence Chardon and Moez Dawood, two BBI researchers based in Dr. Lea Starita’s lab, recently presented on their work at the international conference, “CRISPR and Beyond” in the U.K. Here are some of their reflections.

UW Medicine to Honor Jay Shendure as 2022 ‘Inventor of the Year’

October 06, 2022 | by BBI Communications

BBI Scientific Director Dr. Jay Shendure will honored October 13 by UW Medicine as the 2022 “Inventor of the Year.”

Dr. Danny Miller Leads BBI Project Sequencing a Child Within 3 Hours of Birth

September 30, 2022 | by BBI Communications

‘Using technology to make clinical decisions rapidly, helping clinicians determine effective treatments, and enlightening parents about their children’s genetic conditions’

Promising Young Scientist Aleena Arakaki: Helping Address Systemic Health Inequities and Uplifting Marginalized Communities Through an Hawaiian Perspective

September 12, 2022 | by BBI Communications

Many 12-year-olds focus on sports, the latest video-sharing platform, and wonder how to navigate peer-pressure in middle school. For Aleena Arakaki, the emergence into adolescence was an overwhelming and tragic introduction into the mortality of cancer.

BBI Researchers to Present at Upcoming IGVF Conference

September 06, 2022 | by BBI Communications

BBI will be well-represented at the upcoming conference of the Impact of Genomic Variation on Function, (IGVF), September 21 through 23, with presentations by three researchers.

BBI’s Dr. Albert Folch: Combining Passions of Microfluidics, Science, and Art to Drive the Future of Precision Medicine

August 29, 2022 | by BBI Communications

BBI’s Dr. Albert Folch has three passions in life: microfluidics, art, and soccer. It might be difficult to combine all three in one book, but in his latest manuscript, he deftly integrates the first two.

One Year On: BBI's Dr. Colin Pritchard Reflects on Receiving the Catalyst for Precision Medicine Award

August 22, 2022 | by Scientific American Custom Media

The Cancer Community Awards, sponsored by AstraZeneca, presents an individual or organization with the Catalyst for Precision Medicine Award. In this interview, BBI's Dr. Colin Pritchard, recipient of the 2021 award, reflects on his work and the impact of the award.

BBI Faculty Conversations: Dr. Fuki Hisama

August 15, 2022 | by BBI

BBI Member Dr. Fuki Hisama is a professor in the Department of Medical Genetics and medical director of the University of Washington Genetic Medicine Clinic.

An Enlightening Exchange on Research and Public Health Issues Between Anthony Fauci and BBI’s Larry Corey

August 10, 2022 | by BBI Communications

President Biden’s Chief Medical Advisor Dr. Anthony Fauci joined BBI’s Dr. Larry Corey August 9 in an engaging conversation covering their work together on HIV-AIDS starting in the 1980s, as well as sharing insights on the coronavirus, monkeypox, and other significant public health issues.

Researchers Gain Insights on Developmental Defects by Mapping Stages of Fruit Fly Embryo Growth

August 09, 2022 | by The European Molecular Biology Laboratory

Scientists have constructed the most complete and detailed single-cell map of embryo development in any animal to date, using the fruit fly as a model organism.

BBI Interns Committed to Using Science to Improving People’s Lives as Future Researchers or Physicians – or Both

August 08, 2022 | by BBI Communications

One was the valedictorian of her high school class, in a Los Angeles County public school that did not have a college counselor. Another is a member of the Chickasaw Nation. And the third is fluent in Akan, the most widely spoken indigenous language in Ghana, West Africa.

UW Medicine-BBI SCAN Program Sunsetting; Seattle Flu Study becomes Seattle Flu Alliance

July 28, 2022 | by BBI Communications

The Seattle Flu Study (SFS) and Greater Seattle Coronavirus Assessment Network Study (SCAN) are ending their active recruitment and research on July 31, 2022, after years of contributing to scientific discovery and improving public health in Seattle

Associations between Ovarian Cancer Survival and Inflammatory Diet

July 25, 2022 | by BBI Communications

BBI Member Dr. Holly Harris Collaborates on Paper with Researchers at Several Other Institutions Identifying New Insights on Extending Survival Pre-and Post-Diagnosis

Promising Young Scientist Anna-Lisa Doebley: A Penchant for Solving Puzzles Leads to A Passion for Identifying Cancer Subtypes

July 20, 2022 | by BBI Communications

What are three characteristics necessary to identify subtypes of cancer from cell-free DNA? The ability to solve difficult genetic computational problems, a high level of enthusiasm for translational cancer research, and a passion for improving the outcomes for cancer patients.

The Future of Precision Medicine: Analogous to the Discovery of the X-Ray and Development of Radiology

June 30, 2022 | by BBI Communications

BBI’s Dr. Colin Pritchard believes that to chart the future of precision medicine, one needs to look no further than the development of radiology.

BBI Faculty Conversations: Dr. Manu Setty

June 28, 2022 | by BBI

Today we are joined by BBI Member Dr. Manu Setty, assistant professor in the Herbold Computational Biology Program at Fred Hutchinson Cancer Center.

Genome Sciences Hosting ‘DNA Café' featuring Ice Cream and Genomics

June 28, 2022 | by BBI Communications

Genomics and your favorite ice cream sundae: What could be better?

Q&A: Highlights of the 2022 Mutational Scanning Symposium

June 27, 2022 | by BBI Communications

Organizer Dr. Fritz Roth and keynote speakers Drs. Clare Turnbull and Doug Fowler offer their observations and insights of the event and suggestions for the 2023 symposium to be held in the U.K.

BBI’s Andrew Stergachis Named a Pew Biomedical Scholar to Study ‘Uncharted Regions of the Human Genome'

June 23, 2022 | by BBI Communications

Funding ‘provides resources and intellectual freedom to make a lasting impact on the future of epigenetics research’

Promising Young Scientist Florence Chardon: ‘Determined and Focused’ on Overcoming Challenges in Genomics

June 21, 2022 | by BBI Communications

Florence Chardon’s introduction to scientific concepts started when she was old enough to understand dinnertime conversations with her parents and two older sisters. Her mother and father, both European physicists, would hold court usually on one of two topics: science or world politics.

BBI Provides $50,000 Grant to Evaluate Performance of Novel Diagnostic Techniques

June 20, 2022 | by BBI Communications

Funding will enable mentoring of UW Medicine fellow and compare optical genome mapping with proximity ligation sequencing

BBI’s Helen Chu to co-lead regional study on COVID-19 vaccine effectiveness

June 09, 2022 | by UW Medicine Communications

Researchers seeking to 3,500 children and adults to assess how well vaccines protect against COVID-19 infection

Promising Young Scientists: Mohamed Adil:

June 01, 2022 | by BBI Communications

The Relentless Pursuit of Computational Genomics, Biomarkers, and Precision Medicine

BBI Faculty Conversations: Dr. Jay Sarthy

May 27, 2022 | by BBI

BBI Member Dr. Jay Sarthy is an assistant professor of pediatrics in the Division of Hematology, Oncology and Bone Marrow Transplantation at the University of Washington School of Medicine.

BBI's Evan Eichler Named to TIME Magazine's 100 Most Influential

May 25, 2022 | by Excerpted from UW Medicine press release

BBI’s Dr. Evan Eichler has been named to the 2022 TIME 100, the magazine’s annual list of the hundred most influential people over the past year.

Q&A with Dr. Frederick Roth

May 17, 2022 | by BBI Communications

Lead organizer of the 5th Annual Mutational Scanning Symposium, in-person and online, June 13 and 14 in Toronto

Promising Young Scientist Debora Ferede: Compassionate Commitment Toward Underserved Communities

May 16, 2022 | by BBI Communications

It’s become a cliché: “They are wise beyond their years.” Unless you’re referring to Debora Ferede.

Gene that shapes mutation rate variation found in mice

May 12, 2022 | by Michael McCarthy

The finding supports theory that genetic differences between individuals and species can affect the acquisition of mutations.

The Backstory of the First Complete Sequence of the Human Genome

April 29, 2022 | by BBI Communications

A Q&A with BBI researchers reveals why the merger of two sequencing systems was crucial to landmark study

BBI’s Danny Miller Leading New Effort Offering Sequencing Services

April 29, 2022 | by BBI Communications

BBI’s Dr. Danny Miller and the UW’s Nanopore Sequencing Core are providing both targeted and whole genome long read sequencing on the Oxford Nanopore platform to assist other researchers with their projects.

5th Annual Mutational Scanning Symposium Set for June in Toronto

April 28, 2022 | by BBI Communications

With just six weeks away from the opening session, the fifth annual Mutational Scanning Symposium, to be held in-person and online June 13 and 14 in Toronto, now has most of its speakers confirmed.

BBI Faculty Conversations: Dr. Alison Paquette

April 28, 2022 | by BBI

BBI Member Alison Paquette, PhD, is an Assistant Professor in the Department of Pediatrics at the University of Washington School of Medicine and a member of the Seattle Children's Research Institute's Center for Developmental Biology and Regenerative Medicine.

BBI Funds Immunotherapy Research to Help Address Pancreatic and Kidney Cancers, a Project that ‘Exemplifies Precision Medicine’

April 12, 2022 | by BBI Communications

‘Killing is not the hard part for the immune system. The hard part is precisely killing the right thing.’

BBI's Dr. Trevor Bedford: COVID-19 'Likely to Keep Evolving'

April 07, 2022 | by BBI Communications

'The evolution has been remarkably fast so far'

BBI's Dr. Evan Eichler a Lead Author on Paper of First Complete Human Genome Map

April 01, 2022 | by BBI Communications

‘Our view of how humans differ from each other is going to be transformed’

Promising Young Scientists - Amanda Riley: Raising Questions - and Identifying Answers - on the Complexities of Lung Cancer

April 01, 2022 | by BBI Communications

Take one enthusiastic high school science teacher. Combine with summer internships at an international pharmaceutical company and a leading academic research center. The result is an inspired college undergraduate and promising young scientist. That was Amanda Riley seven years ago.

Mentors Helped Launch His Award-winning Career. Now, It’s His Turn.

March 31, 2022 | by Stephanie Perry, UW Medicine Communications Specialist

Alumnus Dr. Colin Pritchard’s genetic research career and his gift to help future researchers.

BBI Hosting Monthly Viruses and Vaccines Seminar Series

March 30, 2022 | by BBI Communications

BBI is sponsoring a “Viruses and Vaccines Seminar Series.”

Fifth Annual Mutational Scanning Symposium Planned for Toronto in June

March 29, 2022 | by BBI Communications

The Brotman Baty Institute is co-sponsoring the fifth annual Mutational Scanning Symposium to be held in-person and online June 13 and 14 in Toronto, followed by an online only poster session on June 16th. More information, including registration details, are available here.

We Study Virus Evolution. Here’s Where We Think the Coronavirus Is Going.

March 28, 2022 | by Sarah Cobey, Jesse Bloom and Tyler Starr, and Nathaniel Lash

NOTE: BBI’s Dr. Jesse Bloom and his lab colleague Dr. Tyler Starr are two of the four co-authors on this op-ed published March 28 in The New York Times. To observe the compelling accompanying graphics, please click here.

Initial SeqFirst Results are Promising for Genome Sequencing on Infants

March 28, 2022 | by BBI Communications

Initial results of the BBI-sponsored SeqFirst Project using whole genome sequencing have demonstrated that “clear opportunities exist to center equity for providing a precise genetic diagnosis that adds value to the care of critically ill newborns.”

UW Regents Approve New Building for BBI Labs and Offices

March 25, 2022 | by BBI Communications

BBI will be part of a major development approved recently by the UW Board of Regents – an 11-story building in the Portage Bay Crossing area on the west side the UW campus.

NIH All of Us Research Program releases genomic dataset

March 17, 2022 | by UW Medicine

The nearly 100,000 whole genome sequences reflect contributions from diverse participants.

‘Roadmap’ tracks trajectories of embryo development

March 14, 2022 | by UW Medicine | Newsroom

BBI scientists and others have mapped out the key molecular changes that orchestrate how embryonic mouse cells differentiate into the diverse cell types that will ultimately form all the different tissues and organs of the adult animal.

BBI Funds ‘Entirely Novel Approach’ to Studying Pediatric Leukemia

February 28, 2022 | by BBI Communications

‘Hope to potentially deliver more information and more confidence in assessing the potential – or even likelihood – of children relapsing’

BBI Faculty Conversations - Dr. Swati Shree

February 28, 2022 | by BBI Communications

Today we are joined by BBI member Dr. Swati Shree, Assistant Professor in Maternal Fetal Medicine in the Department of Obstetrics and Gynecology at the University of Washington.

BAT Lab joining UW Initiative to Combat Wildlife Trafficking

February 17, 2022 | by BBI Communications

The Brotman Baty Institute Advanced Technology Lab (BAT Lab) will soon be evaluating animal and plant specimens as part of a new UW initiative to help combat international wildlife trafficking.

‘Closing the Gap’ Paper Examines BBI’s Progress Toward Resolving Genetic Variants of Unknown Significance

February 14, 2022 | by BBI Communications

“Technological advances are making the routine sequencing of human genomes increasingly practical, including in clinical settings. However, our inability to interpret the clinical consequences of genetic variants discovered by sequencing remains a critical roadblock.”

KUOW interview with Dr. Helen Chu

February 07, 2022 | by BBI Communications

Dr. Helen Chu discusses Covid testing with Kim Malcolm

Vancouver Sun profile of Ashley Doyle

February 02, 2022 | by BBI Communications

Ashley Doyle, a client of BBI’s ConnectMyVariant with hereditary cancer, is making a ‘Herculean effort” to connect with relatives near and far, urging them to seek genetic testing.

Promising Young Scientists: Moez Dawood

January 28, 2022 | by BBI Communications

Moez Dawood: Pushing Himself Outside His Comfort Zone and Using BBI Technologies to Address Unanswered Questions in Human Genetics

Are We Prepared for the Next Pandemic?

January 24, 2022 | by BBI Communications

Storylines: Bloomberg Businessweek documentary examines Seattle Flu Study with BBI’s Drs. Lea Starita and Trevor Bedford

‘Continuum of Expertise’ of International Researchers Examines Pediatric Epilepsy

January 24, 2022 | by BBI Communications

‘It’s one thing to find a genetic variant. But how does that affect the brain architecture, structure, and function? We wanted to know more.’

Chris Evert and the Imperative of Studying Genetic Variants

January 19, 2022 | by Lea Starita

We generate data in our research labs to inform the classification of variants found in people like Chris and Jeanne Evert.

New Commentary Offers Reforms to Regulations That Hindered Seattle Flu Study Surveillance of SARS-CoV-2

January 10, 2022 | by BBI Communications

Public health policy makers cannot move on unless and until a sustainable surveillance system is in place

Dr. Brian Shirts interviewed for 'Conversations That Matter'

January 07, 2022 | by BBI Communications

‘Conversations that Matter’ host Stuart McNish interviews BBI’s Dr. Brian Shirts who articulates the imperative of genetic testing and the services of connecting with family members through ConnectMyVariant.

International Collaboration Leads to New Insights on Fetal Brain Development

November 22, 2021 | by BBI Communications

A Flyer, Lecture, and Meeting on Mouse Brains Spawn 4-Year Study and Expected Future Research

BBI Faculty Conversations: Dr. Heather Gustafson

October 28, 2021 | by BBI Communications

Today we are joined by BBI member Dr. Heather Gustafson, Assistant Professor in the Ben Towne Center for Childhood Cancer Research at Seattle Children’s Hospital

Looking Back and Projecting Ahead as AVE Celebrates One Year

October 21, 2021 | by BBI Communications

This October marks the one-year anniversary of the Atlas of Variant Effects (AVE) Alliance.

Scientific American Honors UW Cancer Researcher Colin Pritchard

October 20, 2021 | by BBI Communications

UW Medicine’s Dr. Colin Pritchard, a leader in molecular diagnostics for cancer, has received the Catalyst for Precision Medicine Award from Scientific American.

BBI’s Dr. Doug Fowler: Q&A on NHGRI’s Bold Predictions for Human Genomics by 2030

September 21, 2021 | by BBI Communications

BBI’s Dr. Doug Fowler on September 16 presented at a National Human Genome Institute’s (NHRGI) “Bold Predictions”: The clinical relevance of all encountered genomic variants will be readily predictable, rendering the diagnostic designation “variant of uncertain significance (VUS)” obsolete.

NIH Awards BBI Researchers $16 million as Part of ‘Impact of Genome Variation on Function’ Consortium

September 09, 2021 | by Written by Michael McCarthy for UW Medicine Newsroom

The National Institutes of Health has awarded $16 million to UW Medicine scientists and their collaborators to fund two projects within the consortium. The funding is part of a 5-year, $185-million initiative sponsored by the NIH’s National Human Genome Research Institute.

Demand for coronavirus tests soars in Seattle amid increased travel, concerns about delta variant

August 19, 2021 | by By Paige Cornwell, Seattle Times staff reporter

The Greater Seattle Coronavirus Assessment Network has sent out twice the usual number of its home-based test kits, which are used to track the spread of COVID-19 in the region, said Dr. Lea Starita

Interns Advance BBI’s Work as They ‘Deepen Knowledge and Experience’

August 18, 2021 | by Gailen Greenstein

This year BBI has three undergraduate interns working at the Fred Hutch, Seattle Children’s Hospital, and the UW Medicine: Amira Ellison, Heidi Solis, and Maria E. Benitez-Cortez. Here, each one offers insights into their passions for their work.

New UW Medicine-BBI Study Identifies Association Between Severity of Preeclampsia and Cell-Free DNA

July 28, 2021 | by BBI Communications

A new scientific study led by Brotman Baty Institute members offers insights into pregnant women with preeclampsia and the association between the severity of the condition and high-circulating cell-free DNA.

Hereditary Cancer Project at UW Medicine Brotman Baty Institute for Precision Medicine

July 17, 2021 | by Keith Eldridge, KOMO-TV News

This story briefly explains Dr. Shirts' hereditary cancer study, ConnectMyVariant

Exploring Underlying Causes of Mendelian Conditions Difficult to Solve

July 16, 2021 | by BBI Communications

NIH Funds BBI members to participate in new Mendelian Genomics Research Consortium

‘Leading-Edge’ Technology Enables Scientists to Map Mouse Development

July 01, 2021 | by BBI Communications

New ‘sci-Space’ method, ‘like an intricately folded origami,’ allows measurement and visualization of growth from the moment of conception

BBI Faculty Conversations – Dr. Sarah Baxter

July 01, 2021 | by BBI Communications

BBI member Dr. Sarah Baxter MD, PhD, is Acting Assistant Professor in the Department of Pediatrics at UW, and Attending Physician in Pediatric Rheumatology at Seattle Children’s Hospital.

Two BBI Staff Receive UW ‘Together We Will’ Honors

June 17, 2021 | by BBI Communications

BBI Administrative Director Nola Klemfuss and Research Coordinator Peter Han received the University’s “Together We Will” award for their outstanding contributions during “the extraordinary challenges of 2020.”

Study of Electronic Health Records Demonstrates Value of Data in Referring Patients for Genetic Testing

June 11, 2021 | by BBI Communications

Members of the Brotman Baty Institute for Precision Medicine (BBI) are using electronic health records to identify women with a risk of having a genetic predisposition to breast cancer.

BBI ‘Catalytic Collaboration’ Grant Leads to ‘Extraordinary’ Progress in Research for Directing Treatment of Multiple Myeloma Patients

June 01, 2021 | by BBI COMMUNICATIONS

“Although recent advances have led to a surge in the number of therapies available to treat Multiple Myeloma, it remains a challenge to identify which treatment a patient is most likely to respond to.” Dr. David Coffey, Fred Hutchinson Cancer Research Center

BBI Faculty Conversations: Dr. Sarah Leary

June 01, 2021 | by BBI Communications

BBI member Dr. Sarah Leary is an attending physician in the Cancer and Blood Disorders Center at Seattle Children’s Hospital and Associate Professor of Pediatrics at the University of Washington School of Medicine

Student-led project improves COVID-19 testing efficiency

May 28, 2021 | by BBI Communications

Old protocol ‘required instruments that cost as much as my condo and required pretty specialized training to run,’ research coordinator says.

Pediatric Sequencing Symposium: A Q&A with Dr. Ghayda Mirzaa, Dr. Tim Cherry, and Dr. Samuel Huang

May 26, 2021 | by BBI Communications

On May 19, The Brotman Baty Institute and Seattle Children’s co-hosted a one-day Pediatric Sequencing Symposium. Sessions ranged from the genomics of pediatric epilepsy disorders, to extended family outreach after finding hereditary cancer risk.

BBI ‘Catalytic Collaboration Grant’ funded in 2019 Leads to Promising Genetic Diagnoses of Rare Diseases

May 03, 2021 | by BBI COMMUNICATIONS

“There is a need for better tools to identify a precise genetic diagnosis in individuals when conventional testing approaches have been exhausted.” – Dr. Evan Eichler, Professor of Genome Sciences, UW School of Medicine

BBI’s Jay Shendure and Helen Chu Brief Washington Governor Jay Inslee on Progress on COVID-19

April 19, 2021 | by BBI COMMUNICATIONS

BBI’s Scientific Director Dr. Jay Shendure and Principal Investigator Dr. Helen Chu briefed Washington Governor Jay Inslee on Friday (April 16th) on the institute’s work regarding the Seattle Flu Study, progress on studying COVID-19 transmission and variants, and other issues.

Lasting Impressions: BBI’s Lea Starita and Doug Fowler Reflect on the 2021 Mutational Scanning Symposium

April 08, 2021 | by BBI Communications

BBI co-hosted with the Center for the Multiplex Assessment of Phenotype on April 5, 6, and 7 the fourth annual Mutational Scanning Symposium with global experts sharing their expertise. The Institute's Drs. Lea Starita and Doug Fowler share their observations.

Scientists Launch ‘Herculean’ Project Creating Atlas of Human Genome Variants

April 01, 2021 | by BBI Communications

An international consortium of geneticists, biologists, clinicians, mathematicians, and other scientists is determined to take the study of the human genome to the next level – creating a comprehensive atlas of genetic variants to advance the understanding, diagnosis, and treatment of disease.